|
KMID : 0377619610010010047
|
|
Korean Jungang Medical Journal
1961 Volume.1 No. 1 p.47 ~ p.53
|
|
|
|
|
|
|
|
Abstract
|
|
|
1) Insulin of 0.5 to 400 units per kg was subcutaneously injected to eighty-two healthy rabbits. Thereafter, clinical symptoms, excitement, convulsion and respiratory arrest i. e. death caused by insulin were observed. Blood sugar level and pH of plasma were examined at times when the above-described symptoms were manifested.
2) Lowered blood sugar level, which caused severe clinical symptoms after administration of insulin, and blood sugar lowering rate revealed marked individual differences. However clinical symptoms became worse in proportion to the gradual decrease of the means of the blood sugar level of each groups.
3) In general, as the blood sugar falls below 50mg percent, violent motor restlessness and general tonic convulsion are likely to occur. As the blood sugar level is depressed still below 40 mg per cent, respiratory arrest and death may occur.
4) The blood plasma of rabbits revealed definite alkalosis during general tonic convulsion.
5) Surviving rabbits for 24 hours after injection of insulin showed alkalosis in their plasma.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|